Lipodystrophy


Lipodystrophy
is a medical term used to describe changes in how fat is distributed throughout our bodies, and may cause a number of different problems being seen in people living with HIV/AIDS:

  • A buildup of fat: Some people see an increase in the amount of fat around their gut, and also on the back of their neck and shoulders, and even in their breasts.

  • A loss of fat: This occurs usually in the face, arms, legs, and buttocks. A loss of fat in the face can cause sunken cheeks, and when fat is lost in the arms or legs, the outlines of veins and muscles may show through the skin.

Commonly asked questions about lipodystrophy:

I’m getting fat! Is it lipodystrophy? 

It is important to remember that anti-viral drugs, especially when used in combination, have helped prevent wasting syndrome, and are keeping people alive longer. With improved health and age comes the possibility of weight gain and normal body-shape changes. In other words, it might not be lipodystrophy after all.

How common is lipodystrophy? 

Accurate numbers regarding how many people have lipodystrophy are hard to come by. Some reports suggest that less than 10% of HIV- positive people have lipo, while other reports have found that more than 80% of people currently taking HIV medications suffer from this problem.

Does lipodystrophy affect all people the same?

Some studies have demonstrated that lipodystrophy affects some people differently, depending on their gender.  More research is needed to answer this very important question.

What is the cause of lipodystrophy?

Lipodystrophy was first reported in 1996 when a number of people taking protease inhibitors began noticing abnormal changes in their body shape and size, along with sharp increases in their blood lipid levels. While a number of researchers have spent a lot of time over the past three to four years, researching this topic, they still do not know what causes it. However, most experts agree that it is a side effect of anti HIV therapy.

This fact sheet is produced by the Women Alive Treatment Education & Advocacy program in cooperation with the Office of AIDS Programs & Policy-Los Angeles County, Department of Health Services.